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Mature melanocytic nevus

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Acquired melanoyctic naevus or mole is a common benign tumour, usually appearing during childhood and adolescence. Sun exposure is a causative factor, particularly in childhood. A point mutation in the braf gene (most often v600e) is usually the initiating genetic mutation. Lesions evolve with age, the initial lesion being macular with nests of proliferating.   giant congenital melanocytic nevus is a skin condition characterized by an abnormally dark, noncancerous skin patch (nevus) that is composed of pigment-producing cells called melanocytes. It is present from birth (congenital) or is noticeable soon after birth. The nevus may be small in infants, but it will usually grow at the same rate the body grows and will eventually be at least 40 cm (15.).   a congenital melanocytic nevus is a type of birthmark composed of pigment cells that usually occurs on the head or neck, although it may develop on any area of the body. This birthmark can appear quite large and may even include excess hair, although this varies from person to person. In most cases, a congenital melanocytic nevus is removed for appearance reasons as well as to decrease the.   in practice, nevi often labeled congenital if they have congenital features of melanocytes clustered around follicles, adnexae, nerves and between collagen fibers at base of lesion. Agminate agminated nevus nevi that are clustered, and may be confined to a developmental segment.   for example, melanocytic nevi are composed of nevus cells, which, even though they are basically identical to melanocytes, differ from melanocytes by being arranged in clusters, or nests and by not showing dendritic processes. The nests are usually confined at the tips of the rete ridges. Melanocytic lesions are commonly encountered in dermatopathology and an area which causes some difficulty, i. It is hard to decide in some cases whether a lesion is benign (e. Maturation in the context of melanocytic lesions means (1) the cells get.   the term benign melanocytic nevus refers to a heterogeneous group of nonmalignant melanocytic nevi manifesting either as pigmented or nonpigmented cutaneous lesions.

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